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【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 
【】 
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-3室
【企業(yè)文化】

秦燕研究組研究發(fā)現，在核糖體的翻譯因子結合部位存在一個脯氨酰開關(Proline Switch)，它的構象決定核糖體對翻譯因子的招募與否。深入研究發(fā)現，控制該開關的酶就是翻譯因子。因此，核糖體與翻譯因子之間存在著對彼此的共調控。而這種調控關系，在所有的蛋白質翻譯G蛋白(trGTPase)與核糖體之間存在，說明其具有普遍意義：在翻譯的全部過程中，包括起始、延長、終止和再循環(huán)，都由這個脯氨酰開關調控招募翻譯G蛋白。
這項研究工作與同所的龔為民研究員、許瑞明研究員，以及德國馬普學會分子遺傳研究所K. H. Nierhaus教授合作完成，得到了國家科技部、國家基金委、中國科學院的資助。
2007年，美國國立衛(wèi)生研究院NIH宣布進行為期兩年、總值340萬美元的癌癥基因組圖譜研究計劃(Cancer Genome Atlas pilot program)，這一計劃目標是“測試一種大規(guī)模、系統性分析癌細胞基因組變化的方法的可行性”，為檢測、治療、預防癌癥提供基因組信息。
在過去的幾年里，這一項目陸續(xù)獲得了一些研究成果，而在的這項研究中，由加州大學圣克魯茲分校Buck研究所Christopher Benz和 Christina Yau的研究組采用6種不同的TCGA“平臺技術(platform technologies)”，分析了12種不同腫瘤類型樣品的DNA，RNA和蛋白，希望能從中發(fā)現不同類型的腫瘤如何相互區(qū)分。
Cell:相同癌癥起源的細胞具有更多分子和遺傳上的相似性
研究結果表明相對于癌癥起源的組織類型，如乳房腎臟、膀胱等，相同癌癥起源的細胞類型具有更多分子和遺傳上的相似性。

Qin Yan research group found that ribosome translation factor binding site there is a prolyl switch (Proline Switch), its conformation determines ribosomes on the translation factor recruitment or not. In-depth study found that the enzyme that controls the switch is a translation factor. Therefore, there is a mutual regulation between ribosomes and translation factors. This regulatory relationship, which exists between all the trGTPases and ribosomes, is of universal significance: the entire process of translation, including initiation, elongation, termination, and recycling, is controlled by this Prolyl switch regulation recruits translated G proteins.
This work was done in collaboration with Prof. Gong Weimin, Prof. Xu Ruiming, and Prof. K. H. Nierhaus, Institute of Molecular Genetics, Maple Institute, with the support of the State Ministry of Science and Technology, the State Commission of Science and the Chinese Academy of Sciences.
In 2007, the National Institutes of Health NIH announced a two-year, $ 3.4 million, Cancer Genome Atlas pilot program that aims to "test a large-scale, systematic analysis of cancer Feasibility of Approaches to Cell Genome Changes "to provide genomic information for the detection, treatment and prevention of cancer.
In the past few years, the project has received some research results, and in the latest study, the research team led by Christopher Benz and Christina Yau of the Buck Institute at the University of California, Santa Cruz, used six different TCGA "Platform technologies," analyzes DNA, RNA, and proteins in 12 different tumor types in hopes of discovering how different types of tumors distinguish each other.
Cell: Cells of the same cancer have more molecular and genetic similarities
The results suggest that there are more molecular and genetic similarities in the cell types of the same cancer origin relative to the type of tissue from which the cancer originated, such as breast kidney, bladder, and the like.